D-dimer is a marker of fibrin formation in the blood. Fibrin is a protein involved in the clotting of blood. Rupture of a coronary plaque and subsequent thrombosis marks the core transition from stable coronary artery disease to an acute heart attack. Previous studies reported higher D-dimer concentrations in heart attack patients than for control subjects reflecting that D-dimer is a plasma marker of activated blood clotting. Increased D-dimer concentration during admission for heart attacks predicted major adverse cardiac events during hospitalization. Researchers in Switzerland reported that 3 mg of melatonin reduced stress responses and lowered D-dimer activity. The research suggests that the blunting effect of melatonin on the procoagulant response to acute psychosocial stress is clinically meaningful. Indeed, melatonin resulted in a 20% reduction in stress-induced D-dimer change. In humans, platelet aggregation in vitro was inhibited by melatonin suggesting a dose-response effect. Melatonin may be useful for bodybuilders because it reduces stress and blood coagulation.
Wirtz PH, Bärtschi C, Spillmann M, Ehlert U, von Känel R.
Effect of oral melatonin on the procoagulant response to
acute psychosocial stress in healthy men: a randomized
placebo-controlled study. J Pineal Res.
Similar Bodybuilding Threads: