The movie is about a recently engaged man (Paul Rudd) seeking the perfect "best man" for his wedding. When his fiancée starts to invite all her friends to the wedding (including Jaime Pressly), Rudd sadly realizes that he doesn't have any friends and, most importantly, no one to serve as the "best man" at his wedding. So, he goes on a series of "man dates" in search the perfect platonic relationship. His search of "man love" leads him to decide on Jason Segal as his best man. Segal proves his devotion to Rudd when he sticks up for his friend by taking on Ferrigno (even though he is no match for the Incredible Hulk).