I first started to notice it with Winztrol. Its a knock off from Winny. They removed the methlayted portion thus taking away the "bad liver part" but then people would only report gains at 4-5x the regular dose of winny. This has held true for almost all of these drugs. Not I am sure some of them out there will work great at lower doses and I am just not keeping up with them but I would be weary putting high doses of such things in your body. Its just that much more for your body to use/cleanse out.
I am all for "upping the dosage" as most would say as long as you know what it is doing to your body. A lot of these new things are so untested its hard to know what its doing in your body.
On a side note, is anyone aware of any clinical studies on any of these compounds?