[QUOTE=jornT;652952]Nice try, and I fully expect you not to respond to this as must be pretty clear for you that you cannot win this argument (for the simple reason you are wrong).
What was your original post:
We discussed so far that GH does not increase skeletal muscle protein synthesis/hypertrophy/hyperplasia (your own review said so). And now all in a sudden you come with anti-catabolic shit? That is NOT what you said originally.
So again. The benefits i mention of Growth hormone come from the fact that when growth hormone increases so does the stimulation of IGF-1 synthesis.
IGF-1 effect on skeletal muscle:
Insulin-like growth factor 1 (IGF-1) can induce skeletal muscle hypertrophy, defined as an increase in skeletal muscle mass. Hypertrophy occurs as a result of an increase in the size, as opposed to the number, of pre-existing skeletal muscle fibers. IGF-1's pro-hypertrophy activity comes predominantly through its ability to activate the Phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Novartis Institutes for BioMedical Research Inc., 100 Technology Square room 4210, Cambridge, MA 02139, USA
Do you even realize that you just admit I was right when I said that GH had no beneficial effects with relation to increasing MPS/hypertrophy/hyperplasia, and since that is what we were discussing....
I should have been more specific about why growth hormone was beneficial for skeletal muscle growth b/c of its relationship with IGF-1 synthesis. I will give you that. I will also say that i was under the impression that IGF-1 caused skeletal muscle cell hyperplasia, but that does not appear to be the case. All recent studies I have read show IGF-1 positively effects muscle cell hypertrophy, not hyperplasia. One of those studies is quoted above.
Yeah to bad none of those models are relevant. Your argument was that pulses of these hormones would have beneficial effects in your ATHLETES and now you come with deficiency models. Or do you not understand that deficiency models are not always relevant?
What many athletes and coaches have failed to understand, however, is that athletes can employ specific training regimens and dietary strategies to optimise their natural secretion of human growth hormone (hGH)
Diet, exercise and sleep patterns all play a role in human growth hormone (hGH) secretion.
foods stimulate insulin secretion which, in turn, contributes to a reduction in human growth hormone (hGH)Metabolism 48(9): 1152-6
Part of the reason I allow longer periods between meals. I supplement amino acids in between meals also.
A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. the results showed that oral administration of a combination of two amino acids (1200 mg l-lysine plus 1200 mg l-Arginine Pyroglutamate) provoked a release of pituitary somatotrophin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by radiorecepter assay and somatomedin induction).
We could demonstrate that the association of the two amino acids does result in the release of biological-active hormone able to affect peripheral cellar receptors and thus growth in general.
Insulin is, of course, an equally important factor in cell growth. Even if there are some uncertainties regarding the bioactivity of the substance assayed, there is no doubt the amino acids stimulated insulin as well as HGH: hence, both of the physiologically important growth factors are affected. It should also be noted that the hypoglycemia which follows the insulin peak is a further stimulus to HGH secretion.
Probably the most significant aspect of our findings is that these HGH responses have demonstrated following oral administration of the amino acid complex.
Cited References used in the above study can be obtained from Bio Corp., 204 East 2nd Avenue, Suite 408, San Mateo, California 94401, 1-800-246-9004
The above study clearly demonstrates the effectiveness of blending specific amino acids to achieve increased levels of growth hormone production.
Previous research has demonstrated that ingestion of essential amino acids and their metabolites induce anabolic effects with the potential to augment gains in lean body mass and strength after resistance exercise training.
The purpose of the present study was to examine the effects of an essential amino acid-based formula (Muscle Armor™ (MA); Abbott Laboratories, Abbott Park, IL) containing β-hydroxy-β-methylbutyrate (HMB) on hormonal and muscle damage markers in response to 12 wk of resistance exercise.
Results: Lean body mass, muscle strength, and muscle power significantly (P ≤ 0.05) increased in both groups after training; however, MA supplementation augmented these responses to a significantly greater extent when compared with the CON group. MA supplementation promoted increases in resting and exercise-induced testosterone and resting growth hormone concentrations. In addition, MA reduced preexercise cortisol concentrations. Throughout the training protocol, MA attenuated circulating creatine kinase and malondealdehyde compared with the CON group, suggesting that MA might have influenced a reduction in muscle damage.
Again more evidence to support amino acid supplementation for greater gains through hormone regulation: MA supplementation promoted increases in resting and exercise-induced testosterone and resting growth hormone concentrations. In addition, MA reduced preexercise cortisol concentrations.
Muscle Armor™ (MA) = essential amino acid-based formula
More evidence that suggests that increasing these levels of hormones does in fact make a difference in the composition of an athlete even if they are not supraphysiological increases.