Pal-GHK

PSL has recently started carrying peptides through the Europharmacy Line. I trust EP for all my other needs, and EP is one of the reasons I agreed to become a rep (that and how the reps always treated me, how customer service treated me, etc). I had never heard of Pal-GHK so I decided to do some research. I read through the body building forums about it and was intrigued, so I went to the medical studies for it and was blown away. Here are some snippets:

The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. The human tripeptide GHK was discovered in 1973 as an activity in human albumin that caused old human liver tissue to synthesize proteins like younger tissue. It has high affinity for copper ions and easily forms a copper complex or GHK-Cu. In addition, GHK possesses a plethora of other regenerative and protective actions including antioxidant, anti-inflammatory, and wound healing properties. Recent studies revealed its ability to up- and downregulate a large number of human genes including those that are critical for neuronal development and maintenance.

The human copper-binding tripeptide glycyl-L-histidyl-L-lysine (GHK) is a compound with a long history of safe use in wound healing and antiaging skin care. Since its discovery in 1973, almost four decades of extensive research have established its diverse beneficial actions in many organs and tissues including nervous tissue, skin, intestine, bone, and blood vessels. The molecule has a high affinity for Cu (II) and forms the chelate GHK-Cu. The GHK copper complex (or GHK-Cu) has been proven to exhibit antioxidant, anti-inflammatory, regenerative, and wound healing action.
The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health

WOW! Been used in the medical community since 1973? What else does the study say?

Inflammation and oxidative damage due to the overproduction of proinflammatory cytokines play an important role in the development of AD (Alzheimer's) and other neurodegenerative conditions [41]. In 2001 McCormack et al. established that GHK-Cu decreased proinflammatory cytokine TGF-beta in human fibroblast culture [42]. In 2003 Canapp et al. demonstrated that GHK-Cu improved healing of ischemic wounds and suppresses inflammation by lowering the level of acute-phase inflammatory cytokines such as TGF-beta and TNF-alpha [43].
It might help prevent Alzheimer's and other neurodegenerative diseases.

From wound healing studies, it is known that GHK-Cu helps reestablish blood flow into damaged tissues through a mixture of three actions: angiogenesis (new blood-vessel formation), anticoagulation, and vasodilation. GHK-Cu increases the expression of basic fibroblast growth factor and vascular endothelial growth factor, both of which aid blood vessel formation [45]. In addition GHK-Cu's ability to stimulate synthesis of collagen and elastin is useful in restoring integrity of blood vessel walls.
Helps new blood vessels grow, and strengthens existing ones, which helps wounds heal faster and helps prevent bruising.

Both Sensenbrenner et al. and Lindner et al. found that GHK stimulates the outgrowth of cultured nerves [48, 49]. Ahmed et al. established that nerve stubs placed in a collagen tube impregnated with GHK (used without copper) had an increased production of nerve growth factor and the neurotrophins NT-3 and NT-4 increased migration of cells into collagen tube and sped up the regeneration of nerve fibers. In addition, GHK also increased axon count and proliferation of the Schwann cells compared to the control group [50].
Pal-GHK helps nerves repair themselves and helps new nerves grow in damaged areas.

First evidence that GHK-Cu may regulate an activity of certain genes came from wound healing and skin remodeling studies. By 1983, Pickart had established that GHK-Cu accelerates wound healing and contraction, improves the take of transplanted skin, and also possesses anti-inflammatory actions [53, 54].

Iorio et al. used a repository of transcriptional responses to compounds, the Connectivity Map (cMap) [60], and MANTRA software (http://mantra.tigem.it/) to explore networks of compounds producing similar transcriptional responses. GHK, as one of the compounds studied, increased mRNA production in 268 genes while suppressing 167 [61].
Also, Hong et al. used genome-wide profiling to identify genetic biomarkers (genetic signature) for metastasis-prone colorectal cancer as well as their perturbagens—substances that modulated their expression. GHK suppressed RNA production in 70% of 54 human genes overexpressed in patients with an aggressive metastatic form of colon cancer and was active at a low nontoxic 1 micromolar concentration [62].
Gene mRNA suppression is effectively turning a gene off and increasing the mRNA production effectively makes it better at doing its job. They found Pal-GHK turns off some cancer causing genes while improving the function of skin repair and rejuvenation genes - which drastically helps the body grow new skin.

Epigenetic silencing of certain genes is currently considered the main reason for age-associated increase in tumorogenesis, oxidative stress, and inflammation. It is commonly accepted that human health is at its best until approximately the age of 20–25. It then begins to decline in later years. Recent genetic studies demonstrated accumulation of altered gene products in various tissues starting from the age of 20–25 [64]. In later decades of life, the genes produce less regenerative proteins but more inflammatory and oncogenic genes.

At present, it is not always possible to track gene effects to its protein product; however, we may conclude from all experimental data on GHK-Cu effects that the reversing of gene silencing by GHK has protective and health-promoting benefits.
As we age, the genes that help us heal start to turn off (gene silencing). Pal-GHK not only stops this from happening, but actively restarts these genes!

The human tripeptide GHK has a long history of safe use in wound healing and skin care; it is naturally occurring, nontoxic, and is active at a very low nanomolar concentration. It readily forms complexes with copper, regulating its metabolism and improving its bioavailability. It possesses antioxidant, anti-inflammatory, and regenerative properties, improves circulation, supports stem cell functions, and promotes nerve outgrown and synthesis of neurotrophic factors. Recent studies demonstrated its ability to regulate a large number of human genes. At 1 micromolar it was able to suppress 70% of genes overexpressed in metastatic colon cancer. It upregulates p63 and integrins in epidermal stem cells, increases collagen, glycosaminoglycans, and decorin expression. Our studies with the Broad Institute's Connectivity Map revealed its ability to regulate a large number of human genes including those that are involved in nervous system physiology, development, and maintenance.

Topical application of Pal-GHK was tested to see if it grew hair, and it was found to grow hair as well as minoxidil 5% does. No study has been done yet to see if SubQ will also grow hair, but I am going to take pictures and find out.
https://www.researchgate.net/publica...ct_Hair_Growth

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TL, DR:
Pal-GHK is a wonder peptide that has been in use since 1973. It is a great anti-oxidant, helps prevent Alzheimer's and other age related mental problems, helps new blood vessels grow in damaged areas (which helps healing), helps nerves repair themselves and actually helps new nerves to grow, improves the actions of genes that help in healing while suppressing genes that help cause cancer, turns on the healing genes that went silent as we age, and helps skin grown and rejuvenate. It might even help you regrow your hair as if you are taking minoxidil 5%.

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I am going in for back surgery and will be using Pal-GHK, along with TB500 and HGH in an effort to speed up my healing. The dosing protocol is:


Pal-GHK has a very short half-life, so it should be injected 2 or 3 times a day for maximum results. Even one shot a day will help, but I am going to do 3 to get maximum benefits. It is recommended to do 200-300mcg in each injection. I am going on the high end of the recommendation and doing 333mcg simply because it made the math easy when I preloaded a bunch of slins today. Each bottle of Pal-GHK is 10mg, and each day I will be doing 3 shots of 333mcg, which means 1mg total a day. Therefor each bottle will last 10 days. I have 10 bottles...so I have 100 days worth. There is no recommended maintenance dose to take, and I suspect it would not be helpful to take Pal-GHK all the time, due to its very short half-life. It is a "use it when you need it" peptide.

TB500 does not have a short half-life, so only 3 shots a week are needed, with each shot being 2mg. Each bottle is 2mg, so that makes 3 bottles a week for a total of 4 weeks, so 12 bottles total. It is recommended to take a maintenance dose of 1 or 2 shots a month of 2mg each after the blast of TB500 is done. I plan on doing that if I can afford it.

I am also taking 2IUs a day of Eurotropin HGH. I dropped it down from 4IUs a day to make sure I do not have any false carpal tunnel symptoms from the HGH.

I am really hoping the synergistic effects of these three wonderful items will drastically shorten my recovery time.


So in short, the dosing is:

Pal-GHK: 3 shots a day of 333mcg each for as long as desired.
TB500: 3 shots a week of 2mg each for 4 weeks, then a maintenance dose of 2 shots a month of 2mg each.
HGH: 2IU a day, forever (or at least 8 months to get the full benefits of it - go as long as money will allow).

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And here is that porn I promised. YUMMY!!

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