
The Creator
Mecca V.I.P.
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- Sep 29, 2006
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Compliments of anaboliod (he got this off of islandsupplements.com). I know that the gyno reversing effects of havoc/epidrol/epistane has been mentioned before but I found the science interesting.
Battling Gyno
Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor (ER? and ER?). When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane™(epidrol) works by binding and deactivating the ER? so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ER? is the primary target receptor responsible for growth and proliferation. Epistane™ binds to the ER? and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ER? receptor and AI’s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane™ has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.
Battling Gyno
Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor (ER? and ER?). When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane™(epidrol) works by binding and deactivating the ER? so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ER? is the primary target receptor responsible for growth and proliferation. Epistane™ binds to the ER? and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ER? receptor and AI’s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane™ has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.