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Nitric Oxide Supplements

philosopher

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Nitric Oxide Supplements- Big Claims - Zero Science: NO 2 ways about it.

by Paul Cribb, B.H.Sci HMS
AST Director of Research

Supplements that reportedly increase nitric oxide levels within the body are currently being marketed as powerful muscle builders. The marketers of these supplements claim they increase nitric oxide levels within muscle tissue and a dramatic increase in muscle size, strength is experienced. Other claims also include an increase in fast-twitch muscle fiber strength, endurance, power output, and load capacity from taking these supplements. These reported benefits are quite specific, so I decided to scan the literature for the scientific evidence that supports these claims.

Nitric Oxide ? what is it?

Nitric oxide is a colorless, free radical gas commonly found in tissues of all mammals (it?s also prepared commercially by passing air through an electric arc). Biologically, nitric oxide has been shown to be an important neuro-messenger in a number of vertebrate signal transduction processes. Nitric oxide is used in medical treatment; for example, nitroglycerin ameliorates the pain of angina by supplying nitric oxide to the blood vessels that supply the heart. The popular drug Viagra controls erection by regulating nitric oxide in the penile cartilage chamber.

The Research and the Claims

I don?t know where the marketers obtained their literature on nitric oxide. It looks like they are using the same journals as the companies selling Myostatin inhibitors ? Alice in Wonderland. Although nitric oxide acts as a cell-to-cell communicator for certain metabolic functions, muscle growth is not one of them. After a review of the available literature I cannot find any research that remotely indicates increasing nitric oxide levels plays a part in increasing protein synthesis, contractile strength or any other biochemical pathway that may lead to increases in muscle mass.

For a company to claim their supplement increases ?fast-twitch? muscle strength, the promoters must have instigated or funded some kind of research that involved biopsy procedures and histochemical analyses to extract, assesses and identify these particular muscle fibers from animals or humans, before and after supplementation. However, I could find no documentation (either on their web sites or via a literature scan) that details these findings, only the marketing claims. As far as I?m aware, there is zero scientific evidence supporting the notion that nitric oxide supplements increase ?fast-twitch? muscle strength.

There also appears to be no evidence whatsoever that shows increasing nitric oxide levels enhances endurance, power output, and load capacity.

Arginine alpha-ketogluterate is the ?active? ingredient reported by one company that sells this type of supplement. It is claimed that this compound increases and maintains a constantly high level of nitric oxide in muscle. Nitric oxide is synthesized within the body using the amino acid arginine, the energy cyclic substrate NADPH, and oxygen. Nitric oxide diffuses freely across membranes but it is a transient signaling molecule. Nitric oxide is by nature, a highly reactive gas that has an extremely short life ? less than a few seconds. While there is a lot of research on the effects of nitric oxide, there is no research that shows supplementation with arginine alpha-ketogluterate increases or sustains nitric oxide levels in any human or animal organs.

Can you imagine, a supplement that ?creates dramatic increases in muscle size, strength, endurance, power output, and load capacity?, but not a single study to support these claims. Nothing new here. Unfortunately, this is typical sports nutrition marketing bullxxxx. It's sad, misleading, and shows you just what these companies think of the intelligence level of their target market.

When new products burst onto the market, you the consumer can cut through the advertising hype quite easily. Simply ask the supplement company making the claims to "show you the research". A reference is a start, but the actual research study is particularly what your after. You want to see the study, the protocol, the outcome and the University at which the study was conducted. In the present case, you want to see a study showing were this supplement actually increased nitric oxide above a control group, and you want to see the data that demonstrates an increase in lean muscle mass, significantly more than the group without elevated nitric oxide levels.

The fact is, there is no science supporting any of the claims made for so-called nitric oxide supplements. There is no science showing they have any effect on nitric oxide levels and certainly no science showing in effects on muscle growth or increased performance.

Ask yourself why there is no research to support these companies? wild claims. The simple answer is that research is expensive, make believe products are not. Research provides evidence, fraudulent supplement marketing only delivers hype. It?s far more financially rewarding to sell hype than to produce effective supplements backed by science.

One promoter of a nitric oxide supplement claims to have ?brought creatine supplementation to the market? and that their supplement is ?the perfected version of creatine?. I?m not sure which market is being referred to but creatine has been used as a supplement for over 40 years. And in NO way are nitric oxide supplements a ?perfected version of creatine?. They are nothing like creatine. While creatine is backed by a wealth of research, nitric oxide supplements do not have a shred of scientific evidence that justifies their effectiveness as a bodybuilding supplements.

Bottom line, money spent on these products is money flushed down the toilet.



Read the Real Science
1. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992 6(12):3051-64.

2. Mayer B; Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1997 22(12):477-81.

3. Janabi N; Chabrier S; Tardieu M. Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways. J Immunol 1996 1;157(5):2129-35.

4. Esposito C; Cozzolino A; Porta R; Mariniello L; Buommino E; Morelli F; Metafora V; Metafora S. Protein SV-IV promotes nitric oxide production not associated with apoptosis in murine macrophages. Eur J Cell Biol 2002 81(4):185-96.

5. Eckmann L; Laurent F; Langford TD; Hetsko ML; Smith JR; Kagnoff MF; Gillin FD. Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia. J Immunol 2000 1;164(3):1478-87.

6. Kelly RA; Smith TW. Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol 1996 30;77(13):2C-7C.

7. Stryer L. Biochemistry 4th Ed. Freeman & Co. 1997
 

Q80_Musclehed

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great post philo .. BTW i'm wondering if Vaigra pills have the same combination and is it just a NO2 ??
 

Palmetto

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Good post Philo. I was considering taking some NO2 but I'll save my money for the real muscle builder now. FOOD!
 

patdiddy

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Nice post....... Id rather stock up on real muscle builders like clean animal meat!
 

TJ

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bu, bu, but, Muscle-Tech says this stuff works :confused:



I will admit NO2 gives me great pumps but that's all it does...
 

German_Joe

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good post and remember kids knowing is half the battle

GIJoe1024x768-1.gif
 

CJU

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great post.

just to throw a little bit of n.o. product bashing in....the n.o. products (like the one i own, but stop using a while ago so it now just collects dust in my cupboard) contain caffine. and we all know what that does...jacks up your metabolism which means you burn through calories faster. in other words, make it HARDER to gain muscle because you will have to eat more food to compensate for how many more calories you are burning than usual.

just say NO, to N.O.
 

fallen

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CJU said:
great post.

just to throw a little bit of n.o. product bashing in....the n.o. products (like the one i own, but stop using a while ago so it now just collects dust in my cupboard) contain caffine. and we all know what that does...jacks up your metabolism which means you burn through calories faster. in other words, make it HARDER to gain muscle because you will have to eat more food to compensate for how many more calories you are burning than usual.

just say NO, to N.O.
yeah i noticed that it cantradits it self even on the label, it says do not take if taking an efedra (sp) lol product since it contains caffine and will demish the affects of this product
 

Flex

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CJU said:
great post.

just to throw a little bit of n.o. product bashing in....the n.o. products (like the one i own, but stop using a while ago so it now just collects dust in my cupboard) contain caffine. and we all know what that does...jacks up your metabolism which means you burn through calories faster. in other words, make it HARDER to gain muscle because you will have to eat more food to compensate for how many more calories you are burning than usual.

just say NO, to N.O.
A fast metabolism is a negative? I guess it depends on the person.

:hollister:
 

fallen

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Flex said:
A fast metabolism is a negative? I guess it depends on the person.

:hollister:
Yeah i think they should market it as a fat loss supliment more than muscle builder that would make more sence to me
 

CJU

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Flex said:
A fast metabolism is a negative? I guess it depends on the person.

:hollister:


so, you WANT to have to burn more money on food, AND have to stuff yourself to the point of puking (even more, if you're someone like me with a fast metabolism) all to take a product which only CLAIMS to be a good muscle builder?

i guess it really DOES depend on the person...how crazy the person is, i mean.
:hsughup:
 

DCuts85

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I like NO Products. I don't think that they do all they say they do, but I def feel a pump when on them.
 

Flex

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CJU said:
so, you WANT to have to burn more money on food, AND have to stuff yourself to the point of puking (even more, if you're someone like me with a fast metabolism) all to take a product which only CLAIMS to be a good muscle builder?

i guess it really DOES depend on the person...how crazy the person is, i mean.
:hsughup:
You know what the purpose of a bulk is?

To put on mass and keep your metabolism fast so once you get into dieting mode you have no problems shredding away the fat.

Some people don't have a problem with this (like you), but give yourself a few years and it's likely you will. Unless you have Rocky's genetics.
 

PUMBA

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Flex said:
A fast metabolism is a negative? I guess it depends on the person.

:hollister:
Not in my world loool, I love something that speeds it up, man I walk past a bakery and put 5lbs :bowroflarms:
 

The Creator

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Good post and it is good to see the literature but I have to disagree. Although there isnt any studies to prove the claims, I still have great results from my NO product, Nitrix by BSN, and I know many others who have as well. The main thing is the arginine, and there is proof that arginine dialates blood vessels and obviously this means that we have more blood flowing to the muscles as well as the ability for other supplements and nutrients to more thouroughly enter the blood and flow throughout the body. In the end it is just a little icing on top of a solid diet, its not a steroid just another little pump.
 

pecs

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There is a new muscletech product call NOx9, it promised to pump your whole body up within 9 seconds (nice number) within the 1st dose or your money back! Yeah they say they are so so so confident, backed by months and months and months of resreach. :ughnoes:
 

thicknasty

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I don't believe that N O products have anything to do with adding muscle, but the pumps I get from them really makes my training session more enjoyable. I would never invest any money in it, but BSN has been continuously sending my gym tons of free NO Eplode samples for the employees to try. Since I work there I pretty much get all I want for free. Just one of the perks of working in a gym.
 
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